Thesis of Théotime Grohens

The role of epistatic interactions in fitness landscapes: an in silico experimental evolution approach


In an evolving organism, mutations are linked together by epistatic interactions. The objective of this PhD thesis si to study these interactions and to decipher their prediction potential. By using in silico experimental evolution and the aevol simulation platform, the PhD student will seek for repeatable epistatic patterns and analyse the prediction power offered by these patterns.

Advisor: Guillaume Beslon